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RLX-33

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Chemical Structure| 2784577-71-3 同义名 : -
CAS号 : 2784577-71-3
货号 : A1636537
分子式 : C24H19ClN4O4
纯度 : 99%+
分子量 : 462.885
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(259.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 RLX-33, a potent, selective, and blood-brain barrier (BBB) permeable antagonist of relaxin family peptide 3 (RXFP3), also inhibits relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, and 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. It effectively blocks the increase in feeding induced by the RXFP3-selective agonist R3/I5 in rats, making it suitable for metabolic syndrome research[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.16mL

0.43mL

0.22mL

10.80mL

2.16mL

1.08mL

21.60mL

4.32mL

2.16mL
参考文献

[1]https://pubmed.ncbi.nlm.nih.gov/35594150/

[2]Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59(1):5-8.