CCT251545

产品说明书

Print
Chemical Structure| 1661839-45-7 同义名 : -
CAS号 : 1661839-45-7
货号 : A161333
分子式 : C23H24ClN5O
纯度 : 99%+
分子量 : 421.923
MDL号 : MFCD29472582
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(118.51 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CCT251545, an orally bioavailable and potent WNT signaling inhibitor, exhibits an IC50 of 5 nM in 7dF3 cells[1]. CCT251545 acts as a selective chemical probe for investigating the function of CDK8 and CDK19 in human diseases[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.85mL

2.37mL

1.19mL

23.70mL

4.74mL

2.37mL
参考文献

[1]Mallinger A, et al. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen. J Med Chem. 2015 Feb 26;58(4):1717-35.

[2]Dale T, et al. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat Chem Biol. 2015 Dec;11(12):973-980.