生物活性 | |||
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描述 | Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a key transcriptional coactivator in energy homeostasis that regulates fat and glucose metabolism. SR-18292 selectively increased PGC-1α acetylation at a concentration of 20µM. Treatment of primary hepatocytes with 20µM SR-18292 significantly reduced the ability of glucagon to stimulate the expression of the Pck1 and G6pc genes. SR-18292 at 20µM also significantly suppressed gluconeogenic gene and protein expression induced by ectopic expression of PGC-1α. In a dietary mouse model of type II diabetes mellitus, i.p. injection of SR-18292 at a dose of 45mg/kg for 4 days significantly decreased fasting blood glucose levels and hepatic expression of Pck1 compared with vehicle-treated controls. SR-18292 at the same dosage also significantly enhanced glucose tolerance and insulin sensitivity both in DIO mice and Lepob/ob mice[2]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.73mL 0.55mL 0.27mL |
13.64mL 2.73mL 1.36mL |
27.29mL 5.46mL 2.73mL |
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