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GNF2133

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Chemical Structure| 2561414-56-8 同义名 : -
CAS号 : 2561414-56-8
货号 : A1599775
分子式 : C24H30N6O2
纯度 : 98%+
分子量 : 434.53
MDL号 : MFCD34676630
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 3 mg/mL(6.9 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GNF2133 is a potent, selective, and orally bioavailable DYRK1A inhibitor with an IC50 of 0.0062 μM for DYRK1A and over 50 μM for GSK3β. It displays strong proliferative effectiveness on rat and human primary β-cells, significantly enhances glucose disposal, and boosts insulin secretion. GNF2133 holds potential for research into type 1 diabetes[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.30mL

0.46mL

0.23mL

11.51mL

2.30mL

1.15mL

23.01mL

4.60mL

2.30mL
参考文献

[1]Liu YA, et al. Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133. J Med Chem. 2020 Mar 26;63(6):2958-2973.