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Phytic Acid

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Chemical Structure| 83-86-3 同义名 : 植酸 ;Inositol hexaphosphate;SNF472 free acid;Inositol hexakisphosphate;Inositol polyphosphate
CAS号 : 83-86-3
货号 : A155640
分子式 : C6H18O24P6
纯度 : 60% in water
分子量 : 660.04
MDL号 : MFCD00082309
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(159.08 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 30 mg/mL(45.45 mM)

动物实验配方:
生物活性
描述 Phytic acid (IP6) is a natural antioxidant that is found in cereals, vegetables, nuts, and natural oils. Studies have shown that IP6 decreases the expression of tumor necrosis factor‐α (TNF‐α), halts the cell in G0/G1, activates caspase‐3, and p53 and inhibits the activation of mitogen‐activated protein kinases (MAPKs)[3]. The rice Khira and Mugai which had very low PA (Phytic Acid)(0.30, 0.36g/kg respectively) had higher GI(glycemic index) and α-amylase activity, while Nua Dhusara and the pigmented rice Manipuri black rice (MBR) which had high PA (2.13, 2.98g/kg respectively) showed low α-amylase activity and GI values[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03355287 Iron-deficiency ... 展开 >> Iron Deficiency Anemia Aluminium Intoxication 收起 << Not Applicable Not yet recruiting August 2019 Ethiopia ... 展开 >> Center for Food Science and Nutrition, Addis Ababa University Not yet recruiting Addis Ababa, Ethiopia, 150201 Contact: Kaleab Baye, PhD    +251.911.890489    kaleabbaye@gmail.com    Switzerland Swiss Federal Institute of Technology ETH Zurich Not yet recruiting Zurich, Switzerland, 8092 Contact: Colin Cercamondi, PhD    +41446328634    colin.cercamondi@hest.ethz.ch    Contact: Amrutha Anandaraman, MSc    +41446329341    amrutha.anandaraman@hest.ethz.ch    Principal Investigator: Michael Zimmermann, PhD 收起 <<
NCT02207413 Influenza Phase 3 Completed - -
NCT02207413 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.52mL

0.30mL

0.15mL

7.58mL

1.52mL

0.76mL

15.15mL

3.03mL

1.52mL

参考文献

[1]Kong K, Islam MS, et al. Effect of phytic acid etchant on the structural stability of demineralized dentine and dentine bonding. J Mech Behav Biomed Mater. 2015 Aug;48:145-52.

[2]Lv Y, Zhang Z, et al. Phytic acid attenuates inflammatory responses and the levels of NF-κB and p-ERK in MPTP-induced Parkinson's disease model of mice. Neurosci Lett. 2015 Jun 15;597:132-6.

[3]Silva EO, Bracarense AP. Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems. J Food Sci. 2016 Jun;81(6):R1357-62. doi: 10.1111/1750-3841.13320. Epub 2016 May 3. PMID: 27272247.

[4]Kumar A, Sahu C, Panda PA, Biswal M, Sah RP, Lal MK, Baig MJ, Swain P, Behera L, Chattopadhyay K, Sharma S. Phytic acid content may affect starch digestibility and glycemic index value of rice (Oryza sativa L.). J Sci Food Agric. 2020 Mar 15;100(4):1598-1607. doi: 10.1002/jsfa.10168. Epub 2019 Dec 23. PMID: 31773736.