产品说明书

ART812

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Chemical Structure| 2607138-82-7 同义名 : -
CAS号 : 2607138-82-7
货号 : A1553136
分子式 : C19H16ClF4N3O4
纯度 : 99%+
分子量 : 461.795
MDL号 : MFCD34602688
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(227.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ART812, an orally active inhibitor of DNA polymerase Polθ, has an IC50 of 7.6 nM. Additionally, ART812 shows an IC50 of 240 nM in cell-based microhomology-mediated end joining (MMEJ) assays [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.65mL

4.33mL

2.17mL
参考文献

[1]Zatreanu D, et al. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nat Commun. 2021 Jun 17;12(1):3636.

[2]Peter BLENCOWE, et al. Preparation of heterocyclic compounds for use in the treatment of cancer. WO2021028643 A1.