TDI-10229

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Chemical Structure| 2810887-45-5 同义名 : -
CAS号 : 2810887-45-5
货号 : A1552289
分子式 : C16H16ClN5
纯度 : 99%
分子量 : 313.785
MDL号 : MFCD34567340
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(382.43 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). It demonstrates nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and possesses pharmacokinetic properties in mice suitable for its use as an in vivo tool compound[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.19mL

0.64mL

0.32mL

15.93mL

3.19mL

1.59mL

31.87mL

6.37mL

3.19mL
参考文献

[1]Balbach M, et al. Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization [published online ahead of print, 2021 Aug 31]. Mol Hum Reprod. 2021;gaab054.

[2]Fushimi M, et al. Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). ACS Med Chem Lett. 2021;12(8):1283-1287. Published 2021 Jul 14.