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Cemsidomide

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Chemical Structure| 2504235-67-8 同义名 : CFT7455
CAS号 : 2504235-67-8
货号 : A1548450
分子式 : C28H27N3O4
纯度 : 97%
分子量 : 469.532
MDL号 : N/A
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(53.24 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cemsidomide (CFT7455) is an orally active degrader of the zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), showing promise as an anti-cancer agent. It binds with a high affinity to the cereblon E3 ligase, with a dissociation constant (Kd) of 0.9 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.65mL

2.13mL

1.06mL

21.30mL

4.26mL

2.13mL
参考文献

[1]David Proia, et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1.

[2]James A. Henderson, et al. Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models. Cancer Res (2021) 81 (13_Supplement): LB007.