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PD-1/PD-L1-IN-23

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Chemical Structure| 2597056-04-5 同义名 : -
CAS号 : 2597056-04-5
货号 : A1544098
分子式 : C32H30BrCl2N3O6
纯度 : 99%+
分子量 : 703.407
MDL号 : N/A
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(355.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PD-1/PD-L1-IN-23 is a potent oral inhibitor of PD-1/PD-L1 and serves as an ester prodrug of L7. L7, a derivative of benzo[c][1,2,5]oxadiazole, has been evaluated biologically as an inhibitor of PD-L1. PD-1/PD-L1-IN-23 exhibits substantial antitumor effects in tumor models using syngeneic and PD-L1 humanized mice[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.42mL

0.28mL

0.14mL

7.11mL

1.42mL

0.71mL

14.22mL

2.84mL

1.42mL
参考文献

[1]Liu L, et al. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021;64(12):8391-8409.