Isonicotinamide
产品说明书
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同义名 : | 异烟碱 |
| CAS号 : | 1453-82-3 | |
| 货号 : | A154365 | |
| 分子式 : | C6H6N2O | |
| 纯度 : | 98% | |
| 分子量 : | 122.125 | |
| MDL号 : | MFCD00006432 | |
| 存储条件： |
Pure form Inert atmosphere,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Isonicotinamide, which is a derivative of nicotinamide and does not inhibit Sirt1, on streptozotocin (STZ)-induced diabetes in mice. Isonicotinamide effectively prevented hyperglycemia induced by higher doses of STZ (streptozotocin) (75 and 100mg/kg BW) alone and low-dose STZ (65 mg/kg BW) followed by 6-week high-fat diet in mice. The protective effects of isonicotinamide were associated with decreased apoptosis of β-cells and reductions in both insulin content and insulin-positive area in the pancreas of STZ-administered mice. In addition, isonicotinamide inhibited STZ-induced apoptosis in cultured isolated islets. Isonicotinamide exerts anti-diabetogenic effects by preventing β-cell damage after STZ administration[2]. Only N-(4-pyridyl)isonicotinamide 1 is found to be an efficient hydrogelator with a minimum gelator concentration of 0.37 wt %. A wide range of concentrations (0.37-20 wt %) could be used to form hydrogels[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
8.19mL 1.64mL 0.82mL |
40.94mL 8.19mL 4.09mL |
81.88mL 16.38mL 8.19mL |
| 参考文献 |
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