产品说明书
Hesperidin
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同义名 : | 二氢黄酮甙 ;Hesperetin 7-rutinoside;Cirantin;USAF CF-3;Hesperitin-7-rhamnoglucoside;NSC 44184;Hesperidoside |
| CAS号 : | 520-26-3 | |
| 货号 : | A154091 | |
| 分子式 : | C28H34O15 | |
| 纯度 : | 97% | |
| 分子量 : | 610.561 | |
| MDL号 : | MFCD00075663 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(171.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Hesperidin is a flavonoid present in high concentration in citrus species and has numerous biological properties, principally antioxidant and anti-inflammatory[3]. The AUC values for total hesperitin were 6.82 μM/h after administration of Bg1A-treated hesperidin and 7.91 μM/h after administration of pure hesperitin. In AD mice,after a relatively short-term treatments of 10 days, hesperidin (100 mg/kg) significantly ameliorated deficits in nesting and in social interactive behaviors, and attenuated β-amyloid deposition and microglial activation in brain. Low concentration of hesperitin (0.1 μM) scavenge reactive oxygen species and activate Akt in PC12 cells and increase seladin-1 secondary to estrogen signaling. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03482401 | Breast Cancer | Not Applicable | Active, not recruiting | June 1, 2019 | Spain ... 展开 >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 收起 << |
| NCT03372109 | Body Weight Changes | Not Applicable | Completed | - | United States, Florida ... 展开 >> Life Extension Clinical Research, Inc. Fort Lauderdale, Florida, United States, 33308 收起 << |
| NCT01477281 | Chronic Venous Insufficiency ... 展开 >> Disease 收起 << | Phase 3 | Unknown | August 2012 | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.64mL 0.33mL 0.16mL |
8.19mL 1.64mL 0.82mL |
16.38mL 3.28mL 1.64mL |
| 参考文献 |
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