产品说明书
BMS-986278
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同义名 : | - |
| CAS号 : | 2170126-74-4 | |
| 货号 : | A1537897 | |
| 分子式 : | C22H31N5O5 | |
| 纯度 : | 95% | |
| 分子量 : | 445.512 | |
| MDL号 : | MFCD34604078 | |
| 存储条件： |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(235.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | BMS-986278 exhibits significant potency and oral bioavailability as an antagonist of lysophosphatidic acid receptor 1 (LPA1), with affinity constants (Kb) of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively. Its potential application in the study of pulmonary fibrotic diseases is noteworthy[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.24mL 0.45mL 0.22mL |
11.22mL 2.24mL 1.12mL |
22.45mL 4.49mL 2.24mL |
| 参考文献 |
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