CC-90001

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Chemical Structure| 1403859-14-2 同义名 : -
CAS号 : 1403859-14-2
货号 : A1537895
分子式 : C16H27N5O2
纯度 : 99%
分子量 : 321.418
MDL号 : MFCD33029314
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(373.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CC-90001 is a potent, selective, and orally active inhibitor of c-Jun N-terminal kinase (JNK), showing 12.9-fold selectivity for JNK1 over JNK2 in a cell-based model. It can be employed in idiopathic pulmonary fibrosis research [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.11mL

0.62mL

0.31mL

15.56mL

3.11mL

1.56mL

31.11mL

6.22mL

3.11mL
参考文献

[1]Bennett B, et, al. CC-90001, a Second Generation Jun N-Terminal Kinase (JNK) Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine 2017; 195:A5409.

[2]Kolb M, et, al. Therapeutic targets in idiopathic pulmonary fibrosis. Respir Med. 2017 Oct;131:49-57.