产品说明书

Vidarabine

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Chemical Structure| 5536-17-4 同义名 : Vira-A;NSC 404241;9-beta-Arabinofuranosyladenine;Arabinofuranosyladenine;NSC 247519;Arabinosyladenine;9-β-D-Arabinofuranosyladenine;Adenine Arabinoside;Ara-A
CAS号 : 5536-17-4
货号 : A153495
分子式 : C10H13N5O4
纯度 : 98%
分子量 : 267.241
MDL号 : MFCD00065471
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(187.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Vidarabine (Ara-A) is an antiviral agent particularly effective against herpes simplex and varicella zoster viruses[1].[2]. Vidarabine demonstrates inhibitory activity with IC50 values of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2, indicating its potency against these strains[2]. Additionally, Vidarabine shows anti-orthopoxvirus activity, broadening its antiviral scope[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.74mL

0.75mL

0.37mL

18.71mL

3.74mL

1.87mL

37.42mL

7.48mL

3.74mL
参考文献

[1]Whitley, R., et al., Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs, 1980. 20(4): p. 267-82.

[2]Suzuki M, et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006;72(2):157-161.

[3]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.