JR14a

产品说明书

Print
Chemical Structure| 2411440-41-8 同义名 : -
CAS号 : 2411440-41-8
货号 : A1532786
分子式 : C25H26Cl2N4O3S
纯度 : 95%
分子量 : 533.47
MDL号 : MFCD34471093
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(196.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 JR14a, a potent thiophene antagonist of the human complement C3a receptor, exhibits selectivity for the human C3a receptor over the C5a receptor and can mitigate C3aR-mediated inflammation [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.37mL

1.87mL

0.94mL

18.75mL

3.75mL

1.87mL
参考文献

[1]Rowley JA, et, al. Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity. J Med Chem. 2020 Jan 23;63(2):529-541.