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PROTAC BCR-ABL1 ligand 1

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Chemical Structure| 2489876-34-6 同义名 : -
CAS号 : 2489876-34-6
货号 : A1522268
分子式 : C17H12F3N3O2
纯度 : 99%+
分子量 : 347.291
MDL号 : MFCD32263449
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 PROTAC BCR-ABL1 ligand 1, known as compound GMB-475, serves as a PROTAC ligand that allosterically binds to the BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, leading to the ubiquitination and eventual breakdown of BCR-ABL1[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.88mL

0.58mL

0.29mL

14.40mL

2.88mL

1.44mL

28.79mL

5.76mL

2.88mL
参考文献

[1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation. Cancer Res. 2019 Sep 15;79(18):4744-4753.