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Cyproheptadine HCl

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Chemical Structure| 41354-29-4 同义名 : 盐酸赛庚啶半水合物 ;Cyproheptadine (hydrochloride hydrate);Cyproheptadine hydrochloride sesquihydrate;Peritol;Periactin hydrochloride
CAS号 : 41354-29-4
货号 : A149586
分子式 : C42H50Cl2N2O3
纯度 : 99+%
分子量 : 701.764
MDL号 : MFCD27967225
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(49.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • 5-HT2

    5-HT2, IC50:0.6 nM
描述 Cyproheptadine hydrochloride is an antihistamine and is an antagonist of serotonin and histamine2.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.42mL

0.28mL

0.14mL

7.12mL

1.42mL

0.71mL

14.25mL

2.85mL

1.42mL
参考文献

[1]Saeed SA, Rasheed H, Gilani AU. Synergism interaction between arachidonic acid by 5-hydroxytryptamine in human platelet aggregation is mediated through multiple signalling pathways. Acta Pharmacol Sin. 2003 Oct;24(10):958-64.

[2]Honda M, Nishida T, Ono H. Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol. 2003 Jan 1;458(1-2):91-9.