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Crizotinib HCl

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Chemical Structure| 1415560-69-8 同义名 : PF-02341066 hydrochloride;Crizotinib hydrochloride;Xalkori
CAS号 : 1415560-69-8
货号 : A149466
分子式 : C21H23Cl3FN5O
纯度 : 99%
分子量 : 486.798
MDL号 : MFCD23378578
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(8.22 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(102.71 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Crizotinib hydrochloride is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.05mL

0.41mL

0.21mL

10.27mL

2.05mL

1.03mL

20.54mL

4.11mL

2.05mL
参考文献

[1]Zou HY, Li Q, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007 May 1;67(9):4408-17.

[2]Christensen JG, Zou HY, et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3314-22.