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PU139

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Chemical Structure| 158093-65-3 同义名 : -
CAS号 : 158093-65-3
货号 : A1483452
分子式 : C12H7FN2OS
纯度 : 99%+
分子量 : 246.26
MDL号 : N/A
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(36.55 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PU139 is a strong inhibitor of pan-histone acetyltransferase (HAT). It effectively inhibits the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP), and p300 with IC50 values of 8.39, 9.74, 2.49, and 5.35 μM, respectively [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.06mL

0.81mL

0.41mL

20.30mL

4.06mL

2.03mL

40.61mL

8.12mL

4.06mL
参考文献

[1]Gajer JM, et al. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis. 2015;4(2):e137. Published 2015 Feb 9.

[2]Carneiro VC, et al. Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis. PLoS Pathog. 2014;10(5):e1004116. Published 2014 May 8.