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MF-766

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Chemical Structure| 1050656-06-8 同义名 : Compound 9a
CAS号 : 1050656-06-8
货号 : A1471584
分子式 : C27H21F3N2O3
纯度 : 99%
分子量 : 478.462
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(104.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MF-766 is a potent, selective, and orally active EP4 antagonist with a Ki value of 0.23 nM. In functional testing, MF-766 is a full antagonist with an IC50 value of 1.4 nM[1][2].Cells were pretreated with MF-766 for 1 hour at a concentration of less than 10 μM and then stimulated with IL-2 (50 ng/mL). After 18 hours of action, MF-766 reversed PGE2-inhibited IFN-γ secretion in human NK cells. In addition, the viability of NK cells was not affected by MF-766[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.45mL

2.09mL

1.05mL

20.90mL

4.18mL

2.09mL
参考文献

[1]John Colucci, et al. Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain. Bioorg Med Chem Lett

[2]Yun Wang, et al. Combination of EP 4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both