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(S,R,S)-AHPC-PEG3-propionic acid

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Chemical Structure| 2140807-42-5 同义名 : -
CAS号 : 2140807-42-5
货号 : A1471100
分子式 : C32H46N4O9S
纯度 : 98%+
分子量 : 662.79
MDL号 : MFCD32693314
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 (S,R,S)-AHPC-PEG3-propionic acid is a synthesized conjugate of an E3 ligase ligand and a linker, incorporating the (S,R,S)-AHPC-based VHL ligand and a 3-unit PEG linker utilized in PROTAC technology [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.51mL

0.30mL

0.15mL

7.54mL

1.51mL

0.75mL

15.09mL

3.02mL

1.51mL
参考文献

[1]Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Me