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FIDAS-3

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Chemical Structure| 1266684-01-8 同义名 : -
CAS号 : 1266684-01-8
货号 : A1466954
分子式 : C16H15F2N
纯度 : 95%
分子量 : 259.294
MDL号 : -
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(404.95 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 FIDAS-3, a stilbene derivative, exhibits potent Wnt inhibition activity with an IC50 of 4.9 μM against methionine S-adenosyltransferase 2A (MAT2A). It effectively competes with S-adenosylmethionine (SAM) for MAT2A binding and demonstrates anticancer properties [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.86mL

0.77mL

0.39mL

19.28mL

3.86mL

1.93mL

38.57mL

7.71mL

3.86mL
参考文献

[1]Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803.

[2]Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J Med Chem. 2011 Mar 10;54(5):1288-97.