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SW157765

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Chemical Structure| 332063-87-3 同义名 : -
CAS号 : 332063-87-3
货号 : A1466608
分子式 : C19H13N3O3
纯度 : 99%+
分子量 : 331.325
MDL号 : MFCD01539854
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(75.45 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SW157765 selectively inhibits the non-canonical glucose transporter GLUT8 (SLC2A8). NSCLC cells harboring KRAS/KEAP1 double mutations are particularly vulnerable to SW157765, due to its impact on metabolic and xenobiotic gene regulatory programs modulated by both KRAS and NRF2 [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.02mL

0.60mL

0.30mL

15.09mL

3.02mL

1.51mL

30.18mL

6.04mL

3.02mL
参考文献

[1]Pine SR, et al. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018;7(Suppl 3):S265-S269.

[2]McMillan EA, et al. Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell. 2018;173(4):864-878.e29.