产品说明书

Pyridoxine HCI

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Chemical Structure| 58-56-0 同义名 : 吡哆醇盐酸盐;维生素B6 ;Pyridoxol hydrochloride;Vitamin B6 hydrochloride;Pyridoxine HCl
CAS号 : 58-56-0
货号 : A146452
分子式 : C8H12ClNO3
纯度 : 95%
分子量 : 205.639
MDL号 : MFCD00012807
存储条件:

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 50 mg/mL(243.14 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(243.14 mM)

动物实验配方:
生物活性
描述 Pyridoxine Hydrochloride is a water- soluble pyridine derivative. Pyridoxine exerted a protective potential against AD, attenuated ROS levels, decreased the expressions of cytoplasmic Nrf2, and upregulated whole-cell HO-1 expression[3]. Vitamin B6 (pyridoxine) is closely associated with the functions of the nervous, immune and endocrine systems. It also participates in the metabolic processes of proteins, lipids and carbohydrates. Pyridoxine deficiency may result in neurological disorders including convulsions and epileptic encephalopathy and may lead to infant abnormalities[4]. Moreover, vitamin B6 (Pyridoxine) significantly increased the amount of dream content participants recalled but did not significantly affect dream vividness, bizarreness, or color, nor did it significantly affect other sleep-related variables[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00001166 - Completed - United States, Maryland ... 展开 >> National Eye Institute (NEI) Bethesda, Maryland, United States, 20892 收起 <<
NCT00000638 HIV Infections ... 展开 >> Tuberculosis 收起 << Not Applicable Completed - -
NCT00642408 Multiple Micronutrient Deficie... 展开 >>ncies During Pregnancy 收起 << Phase 4 Completed - Burkina Faso ... 展开 >> Centre Muraz, 2054, Avenue Mamadou KONATE Bobo-Dioulasso, Burkina Faso, BP 390 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.86mL

0.97mL

0.49mL

24.31mL

4.86mL

2.43mL

48.63mL

9.73mL

4.86mL

参考文献

[1]Aufiero E, Stitik TP, et al. Pyridoxine hydrochloride treatment of carpal tunnel syndrome: a review. Nutr Rev. 2004 Mar;62(3):96-104.

[2]Rosenberg JM, Lau-Cam CA, McGuire H. Effects of pyridoxine hydrochloride (vitamin B6) on chlorpromazine-induced serum prolactin rise in male rats. J Pharm Sci. 1979 Sep;68(9):1179-81.

[3]Li C, Wang R, Hu C, Wang H, Ma Q, Chen S, He Y. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124

[4]Ahmad I, Mirza T, Qadeer K, Nazim U, Vaid FH. Vitamin B6: deficiency diseases and methods of analysis. Pak J Pharm Sci. 2013 Sep;26(5):1057-69

[5]Aspy DJ, Madden NA, Delfabbro P. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep. Percept Mot Skills. 2018 Jun;125(3):451-462