产品说明书
Crocetin
 |
同义名 : | 藏红花 ;Transcrocetin;NSC 407300 |
| CAS号 : | 27876-94-4 | |
| 货号 : | A146082 | |
| 分子式 : | C20H24O4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 328.402 | |
| MDL号 : | MFCD00017359 | |
| 存储条件： |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 1 mg/mL(3.05 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Crocetin is an active constituent of saffron (Crocus sativus L.) stigma and exhibits various health-promoting properties including anti-tumor, neuroprotective effects, anti-diabetics, anti-inflammatory, anti-hyperlipidemia, etc[3]. Crocetin could be suggested as a potential dermatological whitening agent in skin care products. Decreased tyrosinase activity, melanin content, tyrosinase and MITF (Microphthalmia-Associated Transcription Factor) proteins levels, and ROS (Reactive Oxygen Species) production showed the inhibition of melanogenesis in B16F10 cells by crocetin[4]. Human Umbilical Vein Endothelial Cells (HUVECs) were incubated with various concentrations of Crocetin (1, 5, 25, 50, and 100 µM) over a period of 72 h. Protein level of VEGFR-1, -2 and p-Akt/Akt, p-eNOS/eNOS ratios were increased 72 h after the treatment of HUVECs with Crocetin. Crocetin promotes HUVECs angiogenesis potential by the modulation of VEGF signaling pathway and increased cell viability[5]. Crocetin significantly inhibited the proliferation of KYSE-150 cells in a dose- and time-dependent manner. Crocetin also markedly induced cell apoptosis. Furthermore, we have found that crocetin not only inhibited the activation of PI3K/AKT, extracellular signal-regulated kinase-1/2 (ERK1/2), and p38 but also upregulated the p53/p21 levelhttps://pubmed.ncbi.nlm.nih.gov/30783055. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01278277 | Retinal Degeneration ... 展开 >> Genetic Disease Single-Gene Defects Macular Dystrophy 收起 << | Phase 1 Phase 2 | Active, not recruiting | December 2017 | Italy ... 展开 >> Policlinico A. Gemelli Rome, Italy, 00168 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.05mL 0.61mL 0.30mL |
15.23mL 3.05mL 1.52mL |
30.45mL 6.09mL 3.05mL |
| 参考文献 |
|---|