Quinolinic acid
产品说明书
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同义名 : | 吡啶-2，3-二羧酸 ;NSC 13127;NSC 403247;NSC 18836 |
| CAS号 : | 89-00-9 | |
| 货号 : | A1460048 | |
| 分子式 : | C7H5NO4 | |
| 纯度 : | 99% | |
| 分子量 : | 167.119 | |
| MDL号 : | - | |
| 存储条件： |
Pure form Keep in dark place,Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 35 mg/mL(209.43 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 3 mg/mL(17.95 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Quinolinic acid, naturally produced in the body, acts as an agonist for the NMDA receptor. It is derived from L-tryptophan through the kynurenine pathway, which may contribute to NMDA receptor-related neuronal damage and dysfunction[1]. In the N18D3 cell line, a hybrid neuronal line created from the fusion of dorsal root ganglions from a 4-week-old Balb/C mouse and N18TG2 mouse neuroblastoma cells, a range of concentrations from 0 to 50 mM was tested over 24 hours. The results showed a proportional decline in cell survival, from 100±0.01% at 5 mM to 45.23±0.01% at 50 mM[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.98mL 1.20mL 0.60mL |
29.92mL 5.98mL 2.99mL |
59.84mL 11.97mL 5.98mL |
| 参考文献 |
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