产品说明书

Diniconazol

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Chemical Structure| 83657-24-3 同义名 : Rac-diniconazole;Diniconazole;Sumi;Ortho spotless;Mixor;Spotless;S-3308L;S-3308
CAS号 : 83657-24-3
货号 : A145773
分子式 : C15H17Cl2N3O
纯度 : 98%
分子量 : 326.221
MDL号 : MFCD01678675
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(321.87 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Diniconazole is a systemic triazole fungicide. Diniconazole disturbed energy metabolism, amino acid metabolism and lipid metabolism[3]. Under the optimized assay conditions, 50% inhibition concentration (IC50) and the limit of detection (LOD, IC10) of clothianidin were 5.08 and 0.021 μg/L, and 13.14 and 0.029 μg/L for diniconazole[4]. Diniconazole induces increases in the hepatic UDP-GT (UDP-glucuronyltransferase) activity and the thyroid hormone excretion from the liver. The thyroid tumorigenesis in rats treated with diniconazole is due to the secondary overstimulant effect on the thyroid by increased serum TSH (thyroid stimulating hormone) level[5]. In addition, the bioaccumulation of diniconazole in Tenebrio molitor was enantioselective with preferential accumulation of S-enantiomer[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.07mL

0.61mL

0.31mL

15.33mL

3.07mL

1.53mL

30.65mL

6.13mL

3.07mL
参考文献

[1]Liu Z, Jin Y, Wang M. Determination of diniconazole in agricultural samples by sol-gel immunoaffinity extraction procedure coupled with HPLC and ELISA. PLoS One. 2012;7(10):e46929.

[2]Yoshida Y, Aoyama Y, et al. Stereo-selective interaction of enantiomers of diniconazole, a fungicide, with purified P-450/14DM from yeast. Biochem Biophys Res Commun. 1986 May 29;137(1):513-9.

[3]Wang Y, Zhu W, Wang D, et al. 1H NMR-based metabolomics analysis of adult zebrafish (Danio rerio) after exposure to diniconazole as well as its bioaccumulation behavior. Chemosphere. 2017;168:1571–1577

[4]Sheng E, Shi H, Zhou L, et al. Dual-labeled time-resolved fluoroimmunoassay for simultaneous detection of clothianidin and diniconazole in agricultural samples. Food Chem. 2016;192:525–530

[5]Hosokawa S, Nakamura J, Ito S, et al. Hormonal disregulation mechanism in the rat thyroid tumor induced by diniconazole. J Toxicol Sci. 1993;18(1):57–67

[6]Liu C, LV XT, Zhu WX, et al. Enantioselective bioaccumulation of diniconazole in Tenebrio molitor larvae. Chirality. 2013;25(12):917–922