Matrine

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Chemical Structure| 519-02-8 同义名 : Matridin-15-one;Vegard;NSC 318810;NSC 146051;(+)-Matrine;α-Matrine
CAS号 : 519-02-8
货号 : A145595
分子式 : C15H24N2O
纯度 : 98+%
分子量 : 248.364
MDL号 : MFCD00210527
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(201.32 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(80.53 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 [E-(+)-Matrine (Matrine) is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and u-receptor agonist. Matrine treatment dose-dependently reduced cell viability and increased the apoptotic rate of HepG2 cells. Matrine treatment induced mitochondrial dysfunction and activated mitochondrial apoptosis by inhibiting protective mitophagy[3]. Matrine activates p38 pathway leading to a caspase-dependent apoptosis by inducing generation of ROS (reactive oxygen species) in NSCLC (Non-small cell lung carcinoma) cells[4]. Matrine can alleviate muscle atrophy and improve myoblast differentiation possibly by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway[5]. MAT (Matrine) significantly improved the D-gal-induced recognition and spatial memory impairment in novel object recognition and Y maze tests, and exercise endurance decreased in the weight-loaded swimming test at 2 and 10 mg/kg[6]. Matrine inhibited proliferation of cancer cells in a dose- and time-dependent manner. Matrine induced cell-cycle arrest at G1/G0 phase, induced apoptosis and reduced expression of Bcl-2 and caspase-3 while up-regulating Bax and cleaved caspase-3 in the four CRC (colorectal cancer) cells[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.03mL

0.81mL

0.40mL

20.13mL

4.03mL

2.01mL

40.26mL

8.05mL

4.03mL
参考文献

[1]Zhang Y, Zhang H, et al.Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology. 2009 Apr;59(3):191-200.

[2]Higashiyama K, Takeuchi Y. et al. Implication of the descending dynorphinergic neuron projecting to the spinal cord in the (+)-matrine- and (+)-allomatrine-induced antinociceptive effects. Biol Pharm Bull. 2005 May;28(5):845-8.

[3]Wei R, Cao J, Yao S. Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways. Cell Stress Chaperones. 2018 Nov;23(6):1295-1309

[4]Tan C, Qian X, Jia R, Wu M, Liang Z. Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells. Oncol Rep. 2013 Nov;30(5):2529-35

[5]Chen L, Chen L, Wan L, Huo Y, Huang J, Li J, Lu J, Xin B, Yang Q, Guo C. Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and mice. Oncol Rep. 2019 Aug;42(2):479-494

[6]Sun K, Yang P, Zhao R, Bai Y, Guo Z. Matrine Attenuates D-Galactose-Induced Aging-Related Behavior in Mice via Inhibition of Cellular Senescence and Oxidative Stress. Oxid Med Cell Longev. 2018 Nov 27;2018:7108604

[7]Gu YY, Chen MH, May BH, Liao XZ, Liu JH, Tao LT, Man-Yuen Sze D, Zhang AL, Mo SL. Matrine induces apoptosis in multiple colorectal cancer cell lines in vitro and inhibits tumour growth with minimum side effects in vivo via Bcl-2 and caspase-3. Phytomedicine. 2018 Dec 1;51:214-225