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DTHIB

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Chemical Structure| 897326-30-6 同义名 : -
CAS号 : 897326-30-6
货号 : A1448618
分子式 : C13H9ClFN3O3
纯度 : 99%+
分子量 : 309.68
MDL号 : MFCD01674066
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(339.06 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DTHIB is a direct and selective inhibitor of heat shock factor 1 (HSF1) with a Kd of 160 nM for binding to the HSF1 DNA binding domain (DBD). It inhibits the HSF1 cancer gene signature (HSF1 CaSig) and selectively promotes the degradation of nuclear HSF1, exhibiting potent anticancer activities that can be utilized in prostate cancer research [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.23mL

0.65mL

0.32mL

16.15mL

3.23mL

1.61mL

32.29mL

6.46mL

3.23mL
参考文献

[1]Bushu Dong, et al. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. Sci Transl Med. 2020 Dec 16;12(574):eabb5647.