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SBP-7455

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Chemical Structure| 1884222-74-5 同义名 : -
CAS号 : 1884222-74-5
货号 : A1448617
分子式 : C16H17F3N4O2
纯度 : 98%+
分子量 : 354.327
MDL号 : N/A
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(338.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SBP-7455 is a potent, orally active dual inhibitor of ULK1/ULK2 autophagy, exhibiting IC50 values of 13 nM and 476 nM in ADP-Glo assays, respectively. SBP-7455 effectively inhibits ULK1/2 enzymatic activity and holds promise for triple-negative breast cancer (TNBC) research [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.82mL

0.56mL

0.28mL

14.11mL

2.82mL

1.41mL

28.22mL

5.64mL

2.82mL
参考文献

[1]Huiyu Ren, et al. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2020 Dec 10;63(23):1460