产品说明书

PF-00489791

Print
Chemical Structure| 853003-48-2 同义名 : PF-489791
CAS号 : 853003-48-2
货号 : A1445357
分子式 : C20H28N8O4S
纯度 : 99%+
分子量 : 476.553
MDL号 : MFCD18782748
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 PF-00489791 (PF-489791) is a potent inhibitor of phosphodiesterase 5A, with an IC50 of 1.5 nM. It enhances the relaxation of blood vessels in the kidney, which helps to lower blood pressure and improve renal function[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.49mL

2.10mL

1.05mL

20.98mL

4.20mL

2.10mL

参考文献

[1]Frank S Menniti, et al. A non-brain penetrant PDE5A inhibitor improves functional recovery after stroke in rats. Restor Neurol Neurosci. 2012;30(4):283-9.