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BEC·HCl

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Chemical Structure| 222638-67-7 同义名 : BEC (hydrochloride);BEC hydrochloride
CAS号 : 222638-67-7
货号 : A143511
分子式 : C5H13BClNO4S
纯度 : 99%+
分子量 : 229.49
MDL号 : MFCD03453539
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(217.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(217.87 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively[3]. Administration of the arginase inhibitor BEC (S-(2-boronoethyl)-l-cysteine) decreased arginase activity and caused alterations in NO homeostasis, which were reflected by increases in S-nitrosylated and nitrated proteins in the lungs from inflamed mice. BEC enhanced perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-kappaB DNA binding, and mRNA expression of the NF-kappaB-driven chemokine genes CCL20 and KC, and lead to further increases in airways hyperresponsiveness[4]. BEC is associated with a decline in FEV1(forced expiratory volume in 1 second), and a consistently high BEC is an independent risk factor for an accelerated decline in FEV1[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.36mL

0.87mL

0.44mL

21.79mL

4.36mL

2.18mL

43.57mL

8.71mL

4.36mL
参考文献

[1]Steppan J, Ryoo S, et al. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4759-64.

[2]Colleluori DM, Ash DE. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62.

[3]Colleluori DM, Ash DE. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62

[4]Ckless K, Lampert A, Reiss J, Kasahara D, Poynter ME, Irvin CG, Lundblad LK, Norton R, van der Vliet A, Janssen-Heininger YM. Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol. 2008 Sep 15;181(6):4255-64

[5]Lee SH, Ahn KM, Lee SY, Kim SS, Park HW. Blood Eosinophil Count as a Predictor of Lung Function Decline in Healthy Individuals. J Allergy Clin Immunol Pract. 2021 Jan;9(1):394-399.e1