Ascorbyl palmitate

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Chemical Structure| 137-66-6 同义名 : 抗坏血酸棕榈酸酯 ;L-Ascorbic acid 6-hexadecanoate;6-O-Palmitoyl-L-ascorbic acid;HSDB 418;CCRIS 3930;BRN 0096552;6-Palmitoylascorbic acid;Vitamin C palmitate;NSC 402451;Ascorbylpalmitic Acid
CAS号 : 137-66-6
货号 : A142721
分子式 : C22H38O7
纯度 : 95%
分子量 : 414.53
MDL号 : MFCD00005377
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(253.3 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Ascorbyl palmitate (AP) is a fatty acid ester endowed with antioxidant properties, used as a food additive and cosmetic ingredient, which is presently produced by chemical synthesis[3]. Ascorbyl palmitate can interact with amylose to form amylose-lipid complexes. About 93% and 66% of ascorbyl palmitate were encapsulated when 15mg and 50mg was respectively added to maize starch during pasting[4]. The growth of HUVECs (Human Umbilical Vein Endothelial Cells)was decreased upon treatment with AP in dose-and time-dependent manner. Furthermore, real time PCR results showed that AP induces apoptosis by up-regulation of caspase-3, 9 and down-regulation of Bcl-2 ratio[5]. Ascorbyl palmitate (AP) and sodium ascorbyl phosphate (SAP) supplementations to skin proved a promising choice for controlling facial sebum secretions and could be evaluated for undesired oily skin and acne reductions for beautifying the facial appearance[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01066182 Learning Beha... 展开 >>viour 收起 << Phase 2 Completed - United Kingdom ... 展开 >> Department of Social Policy and Social Work Oxford, Oxfordshire, United Kingdom, OX1 2ER 收起 <<
NCT03201588 Ophthalmological Disorder Not Applicable Recruiting December 31, 2019 Sweden ... 展开 >> Queen Silvias Childrens Hospital Recruiting Göteborg, Sweden, 41650 Contact: Karin Savman, MD,PhD    +46 ext 739940937    karin.savman@vgregion.se    Contact: Svetlana Najm, MD    +46 ext 738999992    svatlana.najm@vgregion.se    Skanes Universitetssjukhus Recruiting Lund, Sweden Contact: David Ley, Professor    +46 ext 709264824    david.ley@med.lu.se    Contact: Ingrid Pupp, MD,PhD    +46 ext 761712021    ingrid.pupp@med.lu.se    KI Recruiting Stockholm, Sweden, 14157 Contact: Boubou Hallberg, MD.PhD    +46 ext 700021010    boubou.hallberg@karolinska.se    Contact: Dirk Wackernagel, MD    +46 ext 700011758    dirk.wackernagel@karolinska.se 收起 <<
NCT01192269 Healthy Not Applicable Completed - Germany ... 展开 >> Ludwig Maximilians University Munich, Germany, 80337 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.06mL

2.41mL

1.21mL

24.12mL

4.82mL

2.41mL
参考文献

[1]Engstrom N, Saenz-Mendez P, et al. Towards Celiac-safe foods: Decreasing the affinity of transglutaminase 2 for gliadin by addition of ascorbyl palmitate and ZnCl(2) as detoxifiers. Sci Rep. 2017 Mar 6;7(1):77.

[2]Aleman M, Bou R, et al. Oxidative stability of a heme iron-fortified bakery product: Effectiveness of ascorbyl palmitate and co-spray-drying of heme iron with calcium caseinate. Food Chem. 2016 Apr 1;196:567-76.

[3]Tufiño C, Bernal C, Ottone C, Romero O, Illanes A, Wilson L. Synthesis with Immobilized Lipases and Downstream Processing of Ascorbyl Palmitate. Molecules. 2019;24(18):3227. Published 2019 Sep 5

[4]Bamidele OP, Duodu KG, Emmambux MN. Encapsulation and antioxidant activity of ascorbyl palmitate with maize starch during pasting. Carbohydr Polym. 2017;166:202‐208

[5]Sohrabi Y, Mohammadzadeh-Aghdash H, Baghbani E, Dehghan P, Ezzati Nazhad Dolatabadi J. Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive. Adv Pharm Bull. 2018;8(2):341‐346

[6]Khan H, Akhtar N, Ali A. Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers. Drug Res (Stuttg). 2017;67(1):52‐58