Pyrogallol

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Chemical Structure| 87-66-1 同义名 : 焦性没食子酸;连苯三酚;苯-1,2,3-三酚;焦榈酚 ;Antioxidant PY;1,2,3-Trihydroxybenzene;2,3-dihydroxy Phenol;NSC 5035;Fouramine Brown AP;C.I. 76515;Benzene-1,2,3-triol
CAS号 : 87-66-1
货号 : A141606
分子式 : C6H6O3
纯度 : 97%
分子量 : 126.11
MDL号 : MFCD00002192
存储条件:

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(832.61 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(396.48 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 Pyrogallol, an active component of Emblica officinalis extracts, is a kind of polyphenol, and has many biological activities [1-3] . In vitro studies, pyrogallol could inhibit the growth of H441 (lung adenocarcinoma) and H520 (lung squamous cell carcinoma) cell lines, but it had less cytotoxicity on human bronchial epithelium cell line [1] . Besides this, it was found that pyrogallol also contributed to the apoptosis of human platelets, through decreasing the level of intracellular glutathione [2] . In vivo studies, it was observed that pyrogallol had the tumoricidal effect in xenograft nude mice model [1] . In addition, pyrogallol has the ability of inhibiting the vascular smooth muscle cells (VSMC) migration and ameliorating neointima hyperplasia in the carotid ligation mouse [3] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.93mL

1.59mL

0.79mL

39.65mL

7.93mL

3.96mL

79.30mL

15.86mL

7.93mL

参考文献

[1]Yang CJ, Wang CS, et al. Pyrogallol induces G2-M arrest in human lung cancer cells and inhibits tumor growth in an animal model. Lung Cancer. 2009;66(2):162-8.

[2]Bruges G, Venturini W, et al. Pyrogallol Induces Apoptosis in Human Platelets. Folia Biol (Praha). 2018;64(1):23-30.

[3]Ma YD, Thiyagarajan V, et al. Pyrogallol abates VSMC migration via modulation of Caveolin-1, matrix metalloproteinase and intima hyperplasia in carotid ligation mouse. Environ Toxicol Pharmacol. 2016.