产品说明书

MAP4K4-IN-3

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Chemical Structure| 1811510-58-3 同义名 : -
CAS号 : 1811510-58-3
货号 : A1399171
分子式 : C15H12ClN5
纯度 : 99%+
分子量 : 297.742
MDL号 : -
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(30.23 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MAP4K4-IN-3 serves as a potent, selective inhibitor of MAP4K4, demonstrating an IC50 value of 14.9 nM in kinase assays and 470 nM in cellular assays. It is noted for its antidiabetic properties[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.36mL

0.67mL

0.34mL

16.79mL

3.36mL

1.68mL

33.59mL

6.72mL

3.36mL
参考文献

[1]Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based AntidiabeticTreatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.

[2]Dow RL, et al. 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety. J Med Chem. 2018 Apr 12;61(7):3114-3125.