Imidazoleacetic acid HCl

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Chemical Structure| 3251-69-2 同义名 : 1H-咪唑-5-乙酸盐酸盐 ;Imidazolyl-4-acetic acid hydrochloride; Imidazole-4(5)-acetic Acid Hydrochloride
CAS号 : 3251-69-2
货号 : A138638
分子式 : C5H7ClN2O2
纯度 : 97%
分子量 : 162.57
MDL号 : MFCD00012698
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(645.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(307.55 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Imidazoleacetic acid hydrochloride is an endogenous metabolite. IAA-RP (imidazole-4-acetic acid-ribotide) is a neuroregulator acting via I-Rs(imidazol(in)e receptors). IAA-RP (i) is present in brain and tissue extracts that exhibit I-R activity; it is present in neurons of brainstem areas, including the rostroventrolateral medulla, a region where drugs active at I-Rs are known to modulate blood pressure; it is present within synaptosome-enriched fractions of brain where its release is Ca(2+)-dependent, consistent with transmitter function; it produces I-R-linked effects in vitro (e.g., arachidonic acid and insulin release) that are blocked by relevant antagonists; and it produces hypertension when microinjected into the rostroventrolateral medulla[2]. Effective interface engineering in PSCs ( perovskite solar cells) is reported via a multifunctional chemical linker of 4-imidazoleacetic acid hydrochloride (ImAcHCl) that can provide a chemical bridge between SnO2 and perovskite through an ester bond with SnO2 via esterification reaction and an electrostatic interaction with perovskite via imidazolium cation in ImAcHCl and iodide anion in perovskite[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.15mL

1.23mL

0.62mL

30.76mL

6.15mL

3.08mL

61.51mL

12.30mL

6.15mL
参考文献

[1]Prell GD, et al. Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13677-82.

[2]Prell GD, Martinelli GP, Holstein GR, et al. Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors. Proc Natl Acad Sci U S A. 2004;101(37):13677‐13682

[3]Chen J, Zhao X, Kim SG, Park NG. Multifunctional Chemical Linker Imidazoleacetic Acid Hydrochloride for 21% Efficient and Stable Planar Perovskite Solar Cells. Adv Mater. 2019;31(39):e1902902