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PACMA 31

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Chemical Structure| 1401089-31-3 同义名 : -
CAS号 : 1401089-31-3
货号 : A1378788
分子式 : C21H22N2O6S
纯度 : 98%
分子量 : 430.474
MDL号 : MFCD26793891
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(243.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PACMA 31, an irreversible and orally administered inhibitor of protein disulfide isomerase (PDI), has an IC50 of 10 μM. It covalently binds to the active site cysteines of PDI. PACMA 31 is capable of targeting tumors and significantly reduces the growth of ovarian tumors without harming normal tissues. In a dose-dependent manner, PACMA 31 at concentrations ranging from 0 to 10 μM over 24 hours markedly inhibits colony formation in OVCAR-8 cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.62mL

2.32mL

1.16mL

23.23mL

4.65mL

2.32mL
参考文献

[1]Xu S, et al. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012;109(40):16348-16353.