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HPK1-IN-7

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Chemical Structure| 2320462-65-3 同义名 : CompK;compound K;HPK1-IN 7, HPK1-IN7
CAS号 : 2320462-65-3
货号 : A1378139
分子式 : C24H22N6O4
纯度 : 99%+
分子量 : 458.469
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(261.74 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 HPK1-IN-7 is a potent and orally active inhibitor of HPK1 (hematopoietic progenitor kinase 1, MAP4K1), exhibiting an IC50 of 2.6 nM, along with remarkable family and kinome selectivity. It demonstrates selectivity against IRAK4 (59 nM) and GLK (140 nM), and exhibits robust efficacy in the MC38 syngeneic tumor model when combined with anti-PD1 [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.91mL

2.18mL

1.09mL

21.81mL

4.36mL

2.18mL
参考文献

[1]Degnan AP, et al. Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1. ACS Med Chem Lett. 2021;12(3):443-450. Published 2021 Feb 19.