TRPM4-IN-1

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Chemical Structure| 351424-20-9 同义名 : CBA;TRPM4-IN-5;TRPM4 IN-5, CBA;Transient Receptor Potential Melastatin 4 Inhibitor 5;TRPM4 inhibitor 5;Compound 5
CAS号 : 351424-20-9
货号 : A1365324
分子式 : C15H11Cl2NO4
纯度 : 99%+
分子量 : 340.158
MDL号 : MFCD01930120
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(249.88 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 TRPM4-IN-1 (CBA) acts as a powerful and specific blocker of the TRPM4 cation channel, with an IC50 value of 1.5 μM. This inhibitor is applicable in the study of heart diseases and prostate cancer[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.94mL

0.59mL

0.29mL

14.70mL

2.94mL

1.47mL

29.40mL

5.88mL

2.94mL
参考文献

[1]Lijo Cherian Ozhathil, et al. Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br J Pharmacol. 2018 Jun; 175(12): 2504–2519.

[2]Clémence Delalande, et al. Optimizing TRPM4 inhibitors in the MHFP6 chemical space. Eur J Med Chem. 2019 Mar 15;166:167-177.