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ZED-1227

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Chemical Structure| 1542132-88-6 同义名 : -
CAS号 : 1542132-88-6
货号 : A1364885
分子式 : C26H36N6O6
纯度 : 98%
分子量 : 528.601
MDL号 : MFCD30532544
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(227.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ZED-1227 is a targeted and orally bioavailable inhibitor of transglutaminase 2 (TG2) with an IC50 of 45 nM. It is effective in blocking inflammation-driven TG2 expression and activity, making it a candidate for celiac disease (CeD) research[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.89mL

0.38mL

0.19mL

9.46mL

1.89mL

0.95mL

18.92mL

3.78mL

1.89mL
参考文献

[1]Manu Encalada, et al. The Oral Transglutaminase 2 (TG2) Inhibitor Zed1227 Blocks TG2 Activity in a Mouse Model of Intestinal Inflammation. Gastroenterology. 154(6):S-490.

[2]Christian Büchold, et al. Pyridinone derivatives as tissue transglutaminase inhibitors. WO2014012858A1.