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JNJ-42226314

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Chemical Structure| 1252765-13-1 同义名 : -
CAS号 : 1252765-13-1
货号 : A1364870
分子式 : C26H24FN5O2S
纯度 : 98%
分子量 : 489.565
MDL号 : MFCD32671350
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(510.66 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 JNJ-42226314 is a competitive, highly selective, and reversible non-covalent monoacylglycerol lipase (MAGL) inhibitor. It exhibits dose-dependent augmentation of the major endocannabinoid 2-arachidonoylglycerol (2-AG) and demonstrates efficacy in neuropathic and inflammatory pain models[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.04mL

0.41mL

0.20mL

10.21mL

2.04mL

1.02mL

20.43mL

4.09mL

2.04mL
参考文献

[1]Wyatt RM, et al.Pharmacologic characterization of JNJ-42226314, [1-(4-fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a reversible, selective and potent monoacylglycerol lipase inhibitor.J Pharmacol Exp Ther. 20