产品说明书

MHI-148

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Chemical Structure| 172971-76-5 同义名 : -
CAS号 : 172971-76-5
货号 : A1362841
分子式 : C42H52BrClN2O4
纯度 : 99%+
分子量 : 764.23
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 20 mg/mL(26.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Photodynamic therapy (PDT) is a burgeoning method for cancer therapy attribute to low side effect, minimal invasiveness, and high space-time selectivity[1]. IR-808 is a PDT photosensitizer with cancer-targeting ability and near-infrared (NIR) sensitivity[2]. When irradiated by tissue-penetrable 808 nm light, the IR-808 greatly absorbs 808 nm photons and then emit a broadband peak which overlaps perfectly with the absorption of Nd3+ and Yb3+. The Nd3+/Yb3+ incorporated shell synergistically captures the emitted NIR photons to illuminate NaGdF4:Yb,Er zone and then radiate ultra-bright green and red emissions. The visible emissions simultaneously activate the dual-photosensitizer to produce a large amount of ROS and, importantly, low heating effects[3]. IR-808 could be internalized selectively by malignant cells of samples, and these malignant cells could be easily distinguished from normal cells under a fluorescence microscope. The positive rates between cytological analysis and the IR-808 staining method were 86% (24/28) and 79% (22/28), respectively. An excellent concordance level (Kappa = 0.752, P < 0.001) was observed between the two methods[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.31mL

0.26mL

0.13mL

6.54mL

1.31mL

0.65mL

13.09mL

2.62mL

1.31mL
参考文献

[1]B. Liu, C. X. Li, Z. Y. Cheng, Z. Y. Hou, S. S. Huang and J. Lin, Functional nanomaterials for near-infrared-triggered cancer therapy,Biomater. Sci., 2016, 4, 890-909.

[2]Gabriel Heras,et al. Muscle RING-finger protein-1 (MuRF1) functions and cellular localization are regulated by SUMO1 post-translational modification. J Mol Cell Biol. 2019. 11(5), 356-370.

[3]Jiating Xu,Piaoping Yang,et al. Highly Emissive Dye-Sensitized Upconversion Nanostructure for Dual-Photosensitizer Photodynamic Therapy and Bioimaging. ACS Nano.2017. 11(4), 4133-4144.

[4]Ying Tian, Jing Sun,et al. A rapid and convenient method for detecting a broad spectrum of malignant cells from malignant pleuroperitoneal effusion of patients using a multifunctional NIR heptamethine dye. Analyst. 2015. 140(3), 750-5.