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(1E)-CFI-400437 2HCl

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Chemical Structure| 1247000-76-5 同义名 : (1E)-CFI-400437 dihydrochloride
CAS号 : 1247000-76-5
货号 : A1362661
分子式 : C29H30Cl2N6O2
纯度 : 98%+
分子量 : 565.494
MDL号 : MFCD30347423
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(21.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(1.77 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 (1E)-CFI-400437 dihydrochloride is a potent inhibitor of PLK4 with an IC50 of 0.6 nM and exhibits selectivity against other members of the PLK family (>10 μM). Additionally, (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR, and FLT-3 with IC50 values of 0.37, 0.21, 0.48, and 0.18 μM, respectively. It also demonstrates antiproliferative activity[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.84mL

1.77mL

0.88mL

17.68mL

3.54mL

1.77mL
参考文献

[1]Laufer R, et al. The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents. J Med Chem. 2013;56(15):6069-6087.