产品说明书
DGY-06-116
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同义名 : | - |
| CAS号 : | 2556836-50-9 | |
| 货号 : | A1362232 | |
| 分子式 : | C32H33ClN8O2 | |
| 纯度 : | 98% | |
| 分子量 : | 597.11 | |
| MDL号 : | MFCD32899273 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(418.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Src is among the first oncogenes to be discovered and encodes a non-receptor protein tyrosine kinase that regulates many cancer-related cellular processes including mitogenesis, angiogenesis, adhesion, invasion, migration, and survival. DGY-06-116 is an irreversible and selective covalent inhibitor of Src with an IC50 value of 2.6 nM. DGY-06-116 covalently binds to Src in a manner similar to SM1-71, where the p-loop must kink to establish the covalent bond[1]. | ||
| 作用机制 | DGY-06-116 forms a covalent bond with Cys-280, and hydrophobic interactions with the back pocket significantly contribute to affinity[1]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.67mL 0.33mL 0.17mL |
8.37mL 1.67mL 0.84mL |
16.75mL 3.35mL 1.67mL |
| 参考文献 |
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