产品说明书

E7016

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Chemical Structure| 902128-92-1 同义名 : GPI 21016
CAS号 : 902128-92-1
货号 : A1355216
分子式 : C20H19N3O3
纯度 : 97%
分子量 : 349.383
MDL号 : MFCD25976607
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(71.55 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 E7016 (GPI 21016) is an orally administered PARP inhibitor. It boosts tumor cell radiosensitivity both in vitro andin vivo by inhibiting DNA repair. E7016 serves as a potential anticancer agent[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.31mL

2.86mL

1.43mL

28.62mL

5.72mL

2.86mL
参考文献

[1]Andrea L Russo, et al. In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016. Clin Cancer Res. 2009 Jan 15;15(2):607-12.

[2]W George Lai, et al. A Baeyer-Villiger oxidation specifically catalyzed by human flavin-containing monooxygenase 5. Drug Metab Dispos. 2011 Jan;39(1):61-70.