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SP-96

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Chemical Structure| 2682114-54-9 同义名 : -
CAS号 : 2682114-54-9
货号 : A1352783
分子式 : C25H20FN7O
纯度 : 99%+
分子量 : 453.471
MDL号 : MFCD32858307
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(231.55 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SP-96 is a potent, selective, and non-ATP-competitive inhibitor of Aurora B (IC50=0.316 nM), with >2000 fold selectivity against FLT3 and KIT. It demonstrates selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 is a valuable tool for researching triple negative breast cancer (TNBC)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.03mL

2.21mL

1.10mL

22.05mL

4.41mL

2.21mL
参考文献

[1]Naga Rajiv Lakkaniga,et al. Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression.Eur J Med Chem. 2020 Jul 12;203:112589.