产品说明书

2,5-dihydroxybenzoic acid

Print
Chemical Structure| 490-79-9 同义名 : 2,5-二羟基苯甲酸 ;Gentisic Acid;NSC 78825;NSC 49098;NSC 27224;5-Hydroxysalicylic Acid;Carboxyhydroquinone
CAS号 : 490-79-9
货号 : A134962
分子式 : C7H6O4
纯度 : 98%
分子量 : 154.12
MDL号 : MFCD00002460
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(681.29 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 7 mg/mL(45.42 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 Gentisic acid (GA), a natural compound, widely exists in many plants and have many biological activities, such as antioxidant, anti-inflammatory and antibiotic activities [1] . In vitro studies, it was found that gentisic acid had no cytotoxicity, but had antimutagenic activity at special concentration on HTC cells [1] . Besides this, gentisic acid could also protect rat liver mitochondria (RLM) and human erythrocytes against the oxidation and radiation [2] . In vivo studies, it was observed that gentisic acid had the ability of improving the cardiac hypertrophy and fibrosis in mice through inhibiting ERK1/2 pathway, when given 100 mg/kg/d for 3 weeks [3] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.49mL

1.30mL

0.65mL

32.44mL

6.49mL

3.24mL

64.88mL

12.98mL

6.49mL
参考文献

[1]Cavalcante FML, Almeida IV, et al. Cytotoxicity, mutagenicity, and antimutagenicity of the gentisic acid on HTC cells. Drug Chem Toxicol. 2017 May 16:1-7.

[2]Joshi R, Gangabhagirathi R, et al. Antioxidant activity and free radical scavenging reactions of gentisic acid: in-vitro and pulse radiolysis studies. Free Radic Res. 2012;46(1):11-20.

[3]Sun S, Kee HJ, et al. Gentisic acid attenuates pressure overload-induced cardiac hypertrophy and fibrosis in mice through inhibition of the ERK1/2 pathway. J Cell Mol Med. 2018;22(12):5964-5977.