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AMN082

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Chemical Structure| 97075-46-2 同义名 : -
CAS号 : 97075-46-2
货号 : A1340352
分子式 : C28H30Cl2N2
纯度 : 99%+
分子量 : 465.457
MDL号 : MFCD08702723
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(75.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AMN082 is a selective, orally active and brain-penetrating mGluR7 agonist that directly activates receptor signalling through allosteric sites in the transmembrane domain. In transfected mGluR7-expressing mammalian cells, AMN082 potently inhibited cAMP accumulation and stimulated GTPγS binding with EC50 values of 64-290 nM. AMN082 is selective for other mGluR subtypes and some ionotropic glutamate receptors. AMN082 exhibits an antidepressant effect[1][2]. Preincubation of synaptosomes with AMN082 (1 μM), 10 min before 4-aminopyridine treatment, effectively inhibited 4-aminopyridine-induced glutamate release without altering basal glutamate release[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.21mL

10.74mL

2.15mL

1.07mL

21.48mL

4.30mL

2.15mL
参考文献

[1]Mitsukawa K, et al. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci U S A. 2005;102(51):18712-18717.

[2]Wang CC, et al. Metabotropic glutamate 7 receptor agonist AMN082 inhibits glutamate release in rat cerebral cortex nerve terminal. Eur J Pharmacol. 2018;823:11-18.