产品说明书

DT2216

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Chemical Structure| 2365172-42-3 同义名 : -
CAS号 : 2365172-42-3
货号 : A1339728
分子式 : C77H96ClF3N10O10S4
纯度 : 98%
分子量 : 1542.355
MDL号 : MFCD32701929
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 DT2216, utilizing PROTAC technology, is a potent and selective degrader of BCL-XL, a member of the Bcl-2 family. It effectively degrades BCL-XL protein by engaging the Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 targets various leukemia and cancer cells dependent on BCL-XL while being significantly less harmful to platelets[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.65mL

0.13mL

0.06mL

3.24mL

0.65mL

0.32mL

6.48mL

1.30mL

0.65mL
参考文献

[1]Khan S, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med. 2019 Dec;25(12):1938-1947.