生物活性 | |||
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描述 | DT2216, utilizing PROTAC technology, is a potent and selective degrader of BCL-XL, a member of the Bcl-2 family. It effectively degrades BCL-XL protein by engaging the Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 targets various leukemia and cancer cells dependent on BCL-XL while being significantly less harmful to platelets[1]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
0.65mL 0.13mL 0.06mL |
3.24mL 0.65mL 0.32mL |
6.48mL 1.30mL 0.65mL |
参考文献 |
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