Bleomycin Sulfate
产品说明书
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同义名 : | 硫酸博莱霉素 (混合物) ;Bleomycin (sulfate);NSC125066 sulfate;Blenoxane |
| CAS号 : | 9041-93-4 | |
| 货号 : | A1339440 | |
| 分子式 : | - | |
| 纯度 : | 1.5-2U/mg | |
| 分子量 : | 0 | |
| MDL号 : | MFCD00070310 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 40 mg/mL，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 250 mg/mL |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Bleomycin Sulfate is a glycopeptide antitumor antibiotic with antineoplastic efficacy[1]. Bleomycin sulfate treatment (3.5-4.0 mg/kg; intra-tracheal) on day 0, body weights decrease by day 4 then increases by Day 7 through the end of the study. Intra-tracheal bleomycin produced a statistically significant increase in lung hydroxyproline levels as well as increase in right caudal lung lobe mass[2]. Bleomycin sulfate (intratracheally; 2.5 mg/kg; 1.25 mg/ml, approximately 50 µl per mouse) induces pulmonary fibrosis in male C57BL/6 mice (8 weeks old, average weight approximately 24.5 g) [3]. | ||
| 参考文献 |
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[1]Hecht SM. Bleomycin: new perspectives on the mechanism of action. J Nat Prod. 2000;63(1):158-168. |